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KMID : 1147720110040020102
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Journal of Acupuncture and Meridian Studies
2011 Volume.4 No. 2 p.102 ~ p.106
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Expression of Keratin 10 in Rat Organ Surface Primo-vascular Tissues
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Kim So-Rim
Lee Seul-Ki
Jang Soo-Hwa
Choi Jae-Hong
Lee Byung-Cheon
Hwang In-Koo
Lee So-Yeong
Ryu Pan-Dong
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Abstract
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The primo-vascular system is described as the anatomical structure corresponding to acupuncture meridians and has been identified in several tissues in the body, but its detailed anatomy and physiology are not well understood. Recently, the presence of keratin 10 (Krt10) in primo-vascular tissue was reported, but this finding has not yet been confirmed. In this study, we compared Krt10 expression in primo-vascular tissues located on the surface of rat abdominal organs with Krt10 expression on blood and lymphatic vessels. Krt10 protein (approximately 56.5 kDa) was evaluated by western blot analysis and immunohistochemistry. Krt10 (IR) in the primo-node was visualized as patchy spots around each cell or as a follicle-like structure containing a group of cells. Krt10 IR was also identified in vascular and lymphatic tissues, but its distribution was diffuse over the extracellular matrix of the vessels. Thus Krt10 protein was expressed in all three tissues tested, but the expression pattern of Krt10 in primo-vascular tissue differed from those of blood and lymphatic vascular tissues, suggesting that structural and the regulatory roles of Krt10 in primo-vascular system are different from those in blood and lymphatic vessels.
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KEYWORD
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blood vessel, keratin 10, lymphatic vessel, primo-vascular system
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